Thermo Fisher Scientific IL-12 beta Polyclonal Antibody
IL-12 beta 단백질을 인식하는 Rabbit Polyclonal 항체로, WB, IHC, ICC, ELISA 등 다양한 응용에 적합합니다. Human, Mouse, Rat에 반응하며 Protein A로 정제된 고순도 항체입니다. 세포면역반응 연구 및 염증성 질환 연구에 활용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:200 |
| Immunohistochemistry (Frozen) (IHC-F) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Immunogen range: 201–300/328 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
IL12B (IL-12 p40) encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells with broad biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of a 40 kDa subunit (encoded by IL12B) and a 35 kDa subunit (encoded by IL12A).
This cytokine is expressed by activated macrophages and is essential for Th1 cell development and maintenance of memory/effector Th1 cells, contributing to long-term protection against intracellular pathogens.
Overexpression has been observed in the CNS of multiple sclerosis (MS) patients, suggesting its role in disease pathogenesis. Promoter polymorphisms have also been associated with asthma severity in children.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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