Thermo Fisher Scientific HERPUD1 Polyclonal Antibody
HERPUD1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합하며, 인간, 마우스, 랫트 반응성을 보입니다. Protein A 정제, 1 mg/mL 농도, -20°C 보관 조건.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human HERPUD1 (amino acids 1–100) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the ER stress response. This includes inhibition of translation to prevent further accumulation of unfolded proteins, increased expression of proteins involved in folding (unfolded protein response, UPR), and destruction of misfolded proteins via the ER-associated protein degradation (ERAD) system.
HERPUD1 may play a role in both UPR and ERAD. Its expression is induced by ER stress and contains an ER stress response element in its promoter. The protein has an N-terminal ubiquitin-like domain, may interact with the ERAD system, and has been shown to interact with presenilin proteins, increasing amyloid-beta levels upon overexpression.
Alternative splicing produces multiple transcript variants, some encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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