Thermo Fisher Scientific HSD3B1 Polyclonal Antibody
HSD3B1 단백질을 검출하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot 및 ICC/IF에 사용 가능하며 인간 및 랫트 반응성을 보입니다. 고순도 친화 크로마토그래피 정제, 1 mg/mL 농도, -20°C 보관.
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Thermo Fisher Scientific HSD3B1 Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:3,000 | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Rat |
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthesized peptide derived from human HSD3B1 (Accession P14060), amino acid residues A129–T179 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2852855 |
Product Specific Information
Antibody detects endogenous levels of total HSD3B1.
Target Information
Amyloid beta peptide (Abeta/Beta-amyloid) is the major constituent of amyloid plaques in the brains of individuals afflicted with Alzheimer’s disease. Abeta peptide is 40–43 amino acids long and generated from the beta-amyloid precursor protein (beta APP) through sequential cleavage by beta-secretase (BACE) and gamma-secretase.
Gamma-secretase, a multi-subunit complex containing presenilin-1 and -2, facilitates the final cleavage step, producing amyloid beta peptide.
Abeta forms extracellular filamentous deposits found in amyloid cores, neuritic plaques, and neurofibrillary tangles. These deposits are associated with Alzheimer’s disease, Lewy body dementia, Down’s syndrome, Dutch-type amyloidosis, cerebral amyloid angiopathy, and the Guam Parkinson-Dementia complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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