Thermo Fisher Scientific TADA2L Polyclonal Antibody

Applications

Immunocytochemistry (ICC/IF)

• Tested Dilution: 0.25–2 µg/mL

Product Specifications

Product Specific Information

• Immunogen sequence:
  MDRLGPFSNDP SDKPPCRGCS SYLMEPYIKC AECGPPPFFL CLQCFTRGFE YKKHQSDHTY EIMTSD
• Highest antigen sequence identity to the following orthologs:
  • Mouse: 97%
  • Rat: 99%

Target Information

TADA2L (transcriptional adapter 2-like), also known as TADA2A (transcriptional adapter 2-alpha) or ADA2-like protein, is a 443 amino acid nuclear protein that exists as two alternatively spliced isoforms. While most abundantly expressed in testis, TADA2L is present in all tissues.
It contains one SANT domain and one SWIRM domain, and interacts with GCN5 and GR (NR3C1). Its ability to bind double-stranded DNA allows TADA2L to play a role in chromatin remodeling.
Although it makes up part of the PCAF complex, TADA2L is also a component of the ATAC complex, which exhibits histone acetyltransferase activity on histones H3 and H4.
The gene encoding TADA2L spans 71,408 bases and maps to human chromosome 17q12. Chromosome 7 houses over 1,000 genes, comprises nearly 5% of the human genome, and has been linked to osteogenesis imperfecta, Pendred syndrome, lissencephaly, citrullinemia, and Shwachman-Diamond syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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