Thermo Fisher Scientific cGKI Polyclonal Antibody
Thermo Fisher Scientific의 cGKI Polyclonal Antibody는 PRKG1 단백질 검출용 항체로, WB, IHC, ICC/IF, IP 등 다양한 응용에 적합합니다. Rabbit/IgG 기반의 액상 항체이며, 높은 특이성과 재현성을 제공합니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5 µg/mL | View 1 publication |
| Immunohistochemistry (IHC) | 1:800 | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Immunoprecipitation (IP) | 4 µg/mL | - |
Product Specifications
| Category | Description |
|---|---|
| Published Species | Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 14-residue synthetic peptide corresponding to residues 4–17 of human PKG 1 beta. Tryptophan was substituted for tyrosine at position 9. A terminal cysteine was added and the peptide conjugated to KLH. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1959760 |
Product Specific Information
A suggested positive control is HeLa cell lysate.
Target Information
PRKG1 is a cGMP-dependent serine/threonine kinase that plays an important role in the relaxation of vascular smooth muscle and inhibition of platelet aggregation. PRKG1 proteins regulate cardiovascular and neuronal functions, smooth muscle tone, and cell growth. This gene is highly expressed in smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala. Isoforms Iα and Iβ share identical cGMP-binding and catalytic domains but differ in leucine/isoleucine zipper and autoinhibitory sequences, affecting dimerization and kinase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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