Thermo Fisher Scientific PSMA Recombinant Rabbit Monoclonal Antibody (4X3O6)

Applications

Western Blot (WB)

• Tested Dilution: 1:500 – 1:2,000

Immunocytochemistry (ICC/IF)

• Tested Dilution: 1:50 – 1:200

Product Specifications

Product Specific Information

• Positive test controls include: LNCaP.

Target Information

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family.
The protein acts as a glutamate carboxypeptidase on different substrates, including folate and the neuropeptide N-acetyl-L-aspartyl-L-glutamate.
It is expressed in tissues such as the prostate, central and peripheral nervous system, and kidney.
Mutations may cause impaired folate absorption and hyperhomocysteinemia.
In the brain, expression may be linked to glutamate excitotoxicity-related conditions.
In the prostate, the protein is up-regulated in cancerous cells and serves as a diagnostic and prognostic marker for prostate cancer.
This gene likely originated from a chromosomal duplication event, and alternative splicing produces multiple isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.