Thermo Fisher Scientific ErbB3 Monoclonal Antibody (2B5)
HER-3/ErbB3 단백질을 검출하기 위한 Thermo Fisher Scientific의 마우스 단일클론 항체(2B5). WB, IP, ICC/IF 등 다양한 응용 가능. 인간, 마우스, 랫트 샘플 반응성. 비결합형 액상 형태로 4°C 보관.
- 카탈로그번호
- MA513040
- 판매단위
- pk
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Thermo Fisher Scientific ErbB3 Monoclonal Antibody (2B5)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:100–1:200 | View 7 publications |
| Immunohistochemistry (IHC) | – | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | – | View 1 publication |
| Immunocytochemistry (ICC/IF) | 2 µg/mL | – |
| Immunoprecipitation (IP) | 2 µg/mL | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2B5 |
| Immunogen | Recombinant rat c-erbB-3/HER-3 oncoprotein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10979685 |
Additional Formats
Product Specific Information
MA5-13040 targets HER-3 in IP and WB applications and shows reactivity with Human, Mouse, and Rat samples.
The MA5-13040 immunogen is recombinant rat c-erbB-3/HER-3 oncoprotein.
Target Information
ErbB3 (c-erbB-3/HER-3) is a member of the type I family of growth factor receptors and binds to ligands in the heregulin family.
ErbB3 is over-expressed in various tumors including prostate, bladder, breast, stomach, pancreas, and colon.
Heregulin and EGF stimulate tyrosine phosphorylation of c-erbB-3 to different extents.
The ErbB3 gene is located on chromosome 12q13 and transcribed into a 6.2 kb mRNA encoding a 160/180 kDa glycoprotein.
It encodes a transmembrane receptor tyrosine kinase that forms heterodimers with other EGF receptor family members, activating pathways for cell proliferation or differentiation.
Alternate transcriptional splice variants encoding different isoforms of ErbB3 have been characterized, including a secreted form lacking the intermembrane region.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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