Thermo Fisher Scientific Granzyme B Polyclonal Antibody
Granzyme B 단백질을 인식하는 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. IHC, ICC/IF, Flow Cytometry 등 다양한 응용에 적합하며, 고순도(2 mg/mL) 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 1:10–1:50 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 2–32 amino acids from the N-terminal region of human GZMB |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion, Dialysis, Ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_10984557 |
Target Information
Granzyme B is a member of the granzyme serine protease family found in the granules of cytotoxic T cells and NK cells. It is also known as CGL1 and CTLA-1, expressed in activated cytotoxic T-lymphocytes. Granzyme B is essential for inducing apoptosis in target cells through caspase-3 activation and DNA fragmentation. It interacts with mannose 6-phosphate receptors to trigger cell death and can also activate mitochondrial apoptosis via Bid protein cleavage. Granzymes are neutral serine proteases stored in specialized lytic granules of CTLs and NK cells. Multiple granzymes have been identified in mice, while fewer have been cloned in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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