Thermo Fisher Scientific GFAP Monoclonal Antibody (ASTRO6)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA5-12023 targets Glial Fibrillary Acidic Protein in IF, IHC (P), and WB applications and shows reactivity with Chicken, Human, Porcine, and Rat samples.
The MA5-12023 immunogen is Glial Fibrillary Acidic Protein.
MA5-12023 was successfully used to detect astrocytes in E18 Sprague Dawley primary cortical cells.

Target Information

GFAP (Glial Fibrillary Acidic Protein) is a member of the class III intermediate filament protein family. GFAP is strongly expressed in astrocytes and certain astroglia of the central nervous system, satellite cells of peripheral ganglia, and non-myelinating Schwann cells of peripheral nerves. Neural stem cells also express GFAP.

Antibodies to GFAP are useful as markers of astrocytic cells and are commonly used in brain tumor studies. GFAP is also found in lens epithelium, Kupffer cells of the liver, some salivary tumor cells, and erythrocytes. It helps distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing of the GFAP gene results in multiple transcript variants encoding distinct isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.