Thermo Fisher Scientific Human IL-10 Recombinant Protein, PeproTech
인간 IL-10 재조합 단백질로 면역 조절 및 염증 연구에 사용. E. coli 발현 시스템에서 생산되며, ≥98% 순도와 낮은 엔도톡신 수준(<1 EU/µg)을 가짐. 다양한 세포 기반 기능 분석 및 ELISA에 적합. 실온 배송, -20°C 보관.
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Applications
Western Blot (WB)
- Assay-dependent
Flow Cytometry (Flow)
- Not specified
- Referenced in 1 publication
ELISA
- Assay-dependent
- Referenced in 6 publications
Functional Assay
- Assay-dependent
In vitro Assay (IV)
- Not specified
- Referenced in 149 publications
Miscellaneous PubMed (Misc)
- Not specified
- Referenced in 14 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species | Human |
| Published species | Human, Mouse, Non-human primate, Pig, Virus |
| Expression System | E. coli |
| Amino Acid Sequence | MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N |
| Molecular Weight | 18.6 kDa |
| Class | Recombinant |
| Type | Protein |
| Purity | ≥ 98% (SDS-PAGE, HPLC) |
| Endotoxin Concentration | <1 EU/µg |
| Activity | Co-stimulation with human IL-4 of MC/9 cells. ED50 ≤ 2.0 ng/ml (≥ 5 × 10⁵ units/mg) |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Purification | Purified |
| Contains | No preservative |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient |
Product Specific Information
Recombinant Human IL-10 is an 18.6 kDa protein consisting of 161 amino acid residues.
This product is shipped at ambient temperature. For storage, handling, and reconstitution details, please refer to the lot-specific Certificate of Analysis.
Target Information
IL-10 encodes a cytokine primarily produced by monocytes and to a lesser extent by lymphocytes. It plays a key role in immunoregulation and inflammation by:
- Down-regulating Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages
- Enhancing B cell survival, proliferation, and antibody production
- Blocking NF-kappa B activity
- Regulating the JAK-STAT signaling pathway
Mouse knockout studies indicate IL-10 is essential for intestinal immune regulation. Mutations in IL10 are linked to increased susceptibility to HIV-1 infection and rheumatoid arthritis.
Associated diseases include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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