Thermo Fisher Scientific Cerebellin 4 Polyclonal Antibody

Thermo Fisher Scientific Cerebellin 4 Polyclonal Antibody

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Product Specific Information

Immunogen sequence:
VCDSNPATDS KGSSSSPLGI SVRAANSKVA FSAV

Target Information

Cerebellin (CER), originally isolated from rat cerebellum, is a hexadecapeptide derived from a larger precursor called Cerebellin 1 (precerebellin 1 or Cbln1).
The precerebellin subfamily within the C1q protein family includes four propeptides: Cerebellin 1, Cerebellin 2 (Cbln2), Cerebellin 3 (Cbln3), and Cerebellin 4 (Cbln4).
These family members act as transneuronal regulators of synapse development and synaptic plasticity in various brain regions.
Cerebellin and its metabolite des-Ser(1)Cer are also expressed in extra-cerebellar tissues such as the adrenal gland.
Cerebellin 1, 2, and 3 form homomeric and heteromeric complexes, influencing each other’s degradation and secretion.
Cerebellin 3 cannot form homomeric complexes and requires heteromeric assembly with Cerebellin 1 for secretion.
Reduced Cerebellin levels have been found in brains of patients with olivopontocerebellar atrophy (OPCA) and Shy-Drager syndrome, suggesting its role in disease pathology.

For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.

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