Thermo Fisher Scientific SASS6 Polyclonal Antibody, MaxPab

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG

Class

Polyclonal

Type

Antibody

Immunogen

SASS6 (AAI01027.1, 1 a.a. approximately 490 a.a) full-length human protein. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:SASS6,uniProtId:Q6UVJ0-1,ncbiNodeId:9606,antigenRange:1-657,antigenLength:657,antigenImageFileName:H00163786-B01P_SASS6_Q6UVJ0-1_House_mouse.svg,antigenImageFileNamePDP:H00163786-B01P_SASS6_Q6UVJ0-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: MQSLDDATKQ LDFTRKTLAE KKQELDKLRN EWASHTAALT NKHSQELTNE KEKALQAQVQ YQQQHEQQKK DLEILHQQNI HQLQNRLSEL EVANKDLTER KYKGDSTIRE LKAKLSGVEE ELQRTKQEVL SLRRENSTLD VECHEKEKHV NQLQTKVAVL EQEIKDKDQL VLRTKEAFDT IQEQKVVLEE NGEKNQVQLG KLEATIKSLS AELLKANEII KKLQGDLKTL MGKLKLKNTV TIQQEKLLAE KEEKLQKEQK ELQDVGQSLR IKEQEVCKLQ EQLEATVKKL EESKQLLKNN EKLITWLNKE LNENQLVRKQ DVLGPSTTPP AHSSSNTIRS GISPNLNVVD GRLTYPTCGI GYPVSSAFAF QNTFPHSISA KNTSHPGSGT KVQFNLQFTK PNASLGDVQS GATISMPCST DKENGENVGL ESKYLKKRED SIPLRGLSQN LFSNSDHQRD GTLGALHTSS KPTALPSASS AYFPGQLPNS

Target Information

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.