Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI7E12), TrueMAB
인간 ZEB1 단백질을 인식하는 Mouse IgG2a 단클론 항체. Western blot 및 IHC(P)에서 사용 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 제공. 연구용으로만 사용.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 | - |
| Miscellaneous PubMed (Misc) | - | View 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI7E12 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1)
Acts as a transcriptional repressor and inhibits interleukin-2 (IL-2) gene expression. It modulates promoter activity of ATP1A1 gene depending on cDNA quantity and cell type. Represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) via SMARCA4/BRG1 recruitment. Also represses BCL6 transcription with CTBP1 corepressor. Positively regulates neuronal differentiation and represses RCOR1 transcription during neurogenesis. Mutations can cause corneal dystrophy, posterior polymorphous corneal dystrophy, and Fuchs endothelial dystrophy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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