Thermo Fisher Scientific ZEB1 Monoclonal Antibody (OTI3G6), TrueMAB
ZEB1 단백질을 인식하는 Mouse monoclonal antibody로 Western blot 및 IHC(P) 검증 완료. ZEB2와 교차반응 없음. PBS/BSA/glycerol buffer에 보관하며, -20°C에서 안정적. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:150 |
| Miscellaneous PubMed (Misc) | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI3G6 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–350 of human ZEB1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
This ZEB1 antibody (TA802298) does not cross-react with ZEB2.
Target Information
ZEB1 (Zinc finger E-box-binding homeobox 1) acts as a transcriptional repressor. It inhibits interleukin-2 (IL-2) gene expression and modulates promoter activity of the ATP1A1 gene depending on cDNA quantity and cell type. ZEB1 represses E-cadherin promoters and induces epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. It also represses BCL6 transcription in the presence of the corepressor CTBP1, positively regulates neuronal differentiation, and represses RCOR1 transcription activation during neurogenesis. Mutations in this gene can result in corneal dystrophy, including posterior polymorphous and Fuchs endothelial dystrophies.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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