Thermo Fisher Scientific cGKI Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:3,000
• View 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:100–1:1,000
• View publication

Product Specifications

Product Specific Information

• Recommended positive controls: NIH-3T3, JC
• Predicted reactivity: Mouse (99%)
• Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Target Information

PRKG1 is a cGMP-dependent serine/threonine kinase that plays a key role in vascular smooth muscle relaxation and platelet aggregation inhibition.
It regulates cardiovascular and neuronal functions, modulates cell growth, and is expressed in smooth muscle, platelets, cerebellar Purkinje cells, hippocampal neurons, and the lateral amygdala.
Isoforms Iα and Iβ share identical cGMP-binding and catalytic domains but differ in leucine/isoleucine zipper and autoinhibitory sequences, resulting in distinct dimerization substrates and kinase activity.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.