Thermo Fisher Scientific Human ARC Synthetic Peptide
인간 ARC 단백질의 C-말단 18개 아미노산에 해당하는 합성 펩타이드. 항체 PA5-19906의 블로킹 펩타이드로 사용 가능. PBS(pH 7.2)와 0.1% BSA에 용해된 액상 형태, -20°C 보관. 연구용으로만 사용.
- 카탈로그번호
- PEP0032
- 카테고리
- Protein
- 판매단위
- pk
카탈로그
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Applications
Control (Ctrl)
- Assay-dependent
Blocking Assay (BLOCK)
- Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 18 amino acids near the carboxy terminus of human ARC.
PEP-0032 can be used as a blocking peptide with polyclonal antibody PA5-19906.
Target Information
ARC (also known as NOL3 - Nucleolar protein 3) has two isoforms. Isoform 1 is involved in RNA splicing. Isoform 2 functions as an apoptosis repressor that blocks multiple modes of cell death.
ARC inhibits extrinsic apoptotic pathways in two different ways:
- By interacting with FAS and FADD upon FAS activation, blocking death-inducing signaling complex (DISC) assembly.
- By interacting with CASP8 in a mitochondria localization- and phosphorylation-dependent manner, limiting the amount of soluble CASP8 available for DISC-mediated activation.
ARC also inhibits intrinsic apoptotic pathways in response to a wide range of stresses through interactions with BAX, resulting in BAX inactivation and prevention of mitochondrial dysfunction and release of pro-apoptotic factors.
Mutations affecting the gene can result in myoclonus, familial cortical.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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