Thermo Fisher Scientific West Nile Virus Matrix Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the middle of WNV Matrix protein.

Target Information

West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state.

Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. However, when the viruses are inside infected cells, the matrix protein exists in its “pre-M” form as a heterodimer with the envelope proteins. Cleavage of the “pre-M” protein to its mature form occurs during release of the virus; this cleavage leads to the dissociation of the heterodimers. The WNV receptor has recently been identified as alpha v beta 3 integrin.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.