Thermo Fisher Scientific West Nile Virus Core Antigen Synthetic Peptide

Thermo Fisher Scientific West Nile Virus Core Antigen Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 15 amino acids near the amino terminus of the West Nile Virus (WNV) Core Protein.

Target Information

West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus.
WNV was first isolated in 1937 in the West Nile region of Uganda and has since become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States, with cases reported in every continental state.

Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome, surrounded by a membrane envelope embedded with envelope and matrix proteins. These proteins play a major role in WNV entry into target cells.

The viral core protein is thought to contribute to WNV-associated inflammation via apoptosis induced through the caspase-9 pathway, as delivery of the core gene into the striatum of mouse brain and skeletal muscle resulted in cell death and inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.