Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Alexa Fluor 647

Thermo Fisher Scientific CD8 Monoclonal Antibody (3B5), Alexa Fluor 647

Applications

• Immunohistochemistry (IHC)
  Tested Dilution: -
  View 1 publication

• Flow Cytometry (Flow)
  Tested Dilution: Assay-dependent
  View 2 publications

Product Specifications

Additional Formats Available

• Unconjugated
• Alexa Fluor 405
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• FITC
• Pacific Blue
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 705
• Qdot 800
• TRI-COLOR
• Request custom conjugation

Target Information

Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein belonging to the immunoglobulin receptor family. It plays a crucial role in signal transduction, T cell differentiation, and activation. CD8 is mainly expressed on T cells as a disulfide-linked heterodimer (CD8α/CD8β), functioning as a co-receptor with TCR for MHC class I molecules, while CD4 serves as a co-receptor for MHC-II molecules.
CD8α is essential for MHC-I binding and is also found on subsets of T cells, NK cells, monocytes, and dendritic cells as homodimers. Interaction with MHC-I/peptide complexes recruits Lck kinase, inducing lymphokine production and cytotoxic T lymphocyte (CTL) activation. Activated CTLs are key in pathogen and tumor cell clearance, with differentiation enhanced by IL-2, IL-12, and TGF-β1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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