Thermo Fisher Scientific PD-1 Polyclonal Antibody
PD-1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, WB 및 IHC(P) 분석에 적합합니다. 항원 친화 크로마토그래피로 정제되었으며, 인간·마우스·랫트 반응성을 보입니다. 세포막 위치 확인용 양성 대조는 편도 조직입니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from C-terminus of human PD-1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Tonsil
- Cellular location: Membrane
Target Information
T-cell mediated immune responses are initiated by T lymphocytes stimulated by peptides bound to MHC molecules on antigen-presenting cells (APC). Activated T cells express receptors such as PD-1 (PDCD-1), which mediate inhibitory signals from APCs. PD-1 interacts with ligands PDL-1 and PDL-2 to inhibit immune activation in the absence of danger signals. PD-1 knockout mice exhibit hyperactivated immune systems and autoimmune phenotypes. PD-1 often migrates at higher molecular weight in SDS-PAGE than predicted.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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