Thermo Fisher Scientific PHD3 Recombinant Rabbit Monoclonal Antibody (23GB5275)
PHD3 단백질을 표적으로 하는 Thermo Fisher Scientific의 재조합 토끼 단클론 항체입니다. Western blot에 최적화되어 있으며 인간, 마우스, 랫트 시료에 반응합니다. 액상 형태로 제공되며 -20°C에서 보관합니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PHD3 Recombinant Rabbit Monoclonal Antibody (23GB5275)
Applications
- Western Blot (WB)
Tested Dilution: 1:1,000–1:5,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293F |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 23GB5275 |
| Immunogen | A synthesized peptide derived from human PHD3 (1–239AA) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice (domestic); Dry ice (international) |
Target Information
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates specific prolines in the oxygen-dependent degradation domains (NODD and CODD) of HIF1A and HIF2A, leading to their proteasomal degradation under normoxia. Under hypoxia, hydroxylation is reduced, allowing HIFs to accumulate and activate hypoxia-responsive genes. EGLN3 (PHD3) also regulates apoptosis in cardiomyocytes and neurons, glycolysis through PKM hydroxylation, and DNA damage response via TELO2 hydroxylation.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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