Thermo Fisher Scientific Phospho-Cardiac Troponin I (Ser43) Polyclonal Antibody
심근 트로포닌 I Ser43 인산화형을 인식하는 폴리클로날 항체로, Western blot에 최적화되어 있음. 인간, 마우스, 랫드에 반응하며 다양한 종에서 예측 반응 가능. 고순도 친화 크로마토그래피 정제, 액상 형태로 안정적 보관 가능.
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Applications
Tested Application
- Western Blot (WB): 1:1,000 dilution
- View 1 publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser43 of mouse TNNI3 conjugated to KLH |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~0.25 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 0.1 mg/mL BSA |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2552722 |
Product Specific Information
- Predicted to react with bovine, canine, human, non-human primate, sheep, Xenopus, and zebrafish based on 100% sequence homology.
- Contains enough material for approximately 10 mini-Western blots.
Target Information
Cardiac Troponin I (TnI) is an inhibitory protein in cardiac muscle forming a complex with troponin C (TnC) and troponin T (TnT).
TnT binds to tropomyosin to form a troponin-tropomyosin complex, anchored by TnI binding to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release TnI inhibition, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT is a key diagnostic indicator of heart muscle damage, differentiating angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro.
Mutations in the Cardiac Troponin I gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-35412_Cardiac_Troponin_I_P48787-1_Rabbit.svg, PA5-35412_Cardiac_Troponin_I_P48787-1_Rabbit_PDP.jpeg)
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