Thermo Fisher Scientific CD86 Monoclonal Antibody (BU63), TRI-COLOR
CD86 단백질을 표적하는 BU63 클론의 마우스 단클론 항체로, TRI-COLOR 형광 표지로 멀티컬러 유세포분석에 적합합니다. 488 nm 레이저로 여기되며, 항원제시세포의 CD86 발현 연구에 활용됩니다. 냉장(4°C) 보관 및 암조건 유지.
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Applications
- Flow Cytometry (Flow): Assay-Dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | BU63 |
| Immunogen | B-lymphoblastoid cell line ARH 77 |
| Conjugate | TRI-COLOR™ |
| Excitation / Emission Max | 567 / 671 nm |
| Form | Liquid |
| Storage conditions | 4°C, store in dark |
| Shipping conditions | Wet ice |
Additional Formats
Product Specific Information
The TRI-COLOR® conjugate is a tandem R-phycoerythrin (PE)-Cy5 conjugate that permits simultaneous multicolor labeling and detection of multiple targets with excitation by a single excitation source—the 488 nm line of the argon-ion laser.
Target Information
CD86 is one of two ligands (the other CD80) for CTLA4 and CD28. CD86 acts as a costimulatory molecule in eliciting T-cell help during antigen presentation. Antigen presentation without sufficient co-stimulation involving CD86/CD80 can induce tolerance. CD86 is a type I membrane protein belonging to the immunoglobulin superfamily and is expressed by antigen-presenting cells. It binds to CD28 and cytotoxic T-lymphocyte-associated protein 4 (CTLA4) on T cells, providing either stimulatory or inhibitory signals for T-cell activation. Alternative splicing results in multiple transcript variants encoding different isoforms. Diseases associated with CD86 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
Analyte Specific Reagent
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