Thermo Fisher Scientific Human IKK epsilon Synthetic Peptide

Applications

Control (Ctrl)

• Assay-dependent

Blocking Assay (BLOCK)

• Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 16 amino acids near the carboxy terminus of human IKK epsilon.
PEP-0089 can be used as a blocking peptide with polyclonal antibody PA5-19964.

Target Information

IKBKE is an activator of nuclear factor-kappa-B (NF-κB). Overexpression of IKBKE has been observed in breast cancer cells, and suppression of IKBKE induces cell death.
NF-κB is a ubiquitous transcription factor and an essential mediator of gene expression during immune and inflammatory responses. It mediates the expression of numerous genes in response to extracellular stimuli and is associated with IκB proteins in the cytoplasm, which inhibit NF-κB activity.
IκB is phosphorylated by the IκB kinase (IKK) complex containing IKK-α, IKK-β, and IKK-γ. A novel molecule in the IKK complex, designated IKK-iota/IKK-i, has been identified. IKK epsilon is required for the activation of NF-κB by PMA and T cell receptors but not by TNF-α and IL-1. IKK-iota/IKK-i expression is inducible by TNF-α, IL-1, and LPS in various tissues.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.