Thermo Fisher Scientific TET2 Polyclonal Antibody
TET2 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat에서 반응합니다. WB, IHC, ICC/IF 등 다양한 응용에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. DNA 탈메틸화 연구 및 TET2 관련 질환 연구에 활용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (IHC) | - | 1 publication |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:50–1:100 | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant full length Human TET2 (aa 1–2002) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2720528 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using an epitope-specific immunogen. The purity is greater than 95% as determined by SDS-PAGE.
Target Information
TET2 is a dioxygenase that catalyzes the conversion of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), playing a key role in active DNA demethylation. It further mediates the conversion of 5hmC to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), representing steps in cytosine demethylation.
Additionally, TET2 recruits O-GlcNAc transferase (OGT) to CpG-rich transcription start sites, promoting histone H2B GlcNAcylation.
Mutations in TET2 are associated with Polycythemia vera and Myelodysplastic syndrome.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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