Thermo Fisher Scientific 53BP2 Polyclonal Antibody
53BP2 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체. 인간 시료에 반응하며, 세포 내 면역형광(ICC/IF)에 적합. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성을 제공. 연구용으로만 사용 가능.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 0.25–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human 53BP2. Recombinant protein control fragment (Product #RP-104898) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_2663259 |
Product Specific Information
Immunogen sequence:
TISVPSYPSKS ASVTASSESP VEIQNPYLHV EPEKEVVSLV PESLSPEDVG NASTENSDMP APSPGLDYEP EGVPDNSPNL QNNPEEPNPE APHVLDVYLE
- Highest antigen sequence identity to orthologs: mouse 76%, rat 75%.
Target Information
Regulator that plays a central role in the regulation of apoptosis and cell growth via its interactions.
Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo.
Inhibits the ability of APPBP1 to conjugate NEDD8 to CUL1, thereby decreasing APPBP1 ability to induce apoptosis.
Impede cell cycle progression at G2/M.
Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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