Thermo Fisher Scientific PELI1 Monoclonal Antibody (OTI2H3), TrueMAB
인간 PELI1 단백질(아미노산 1-245)에 특이적인 Mouse IgG1 단클론 항체. Western blot에 적합하며, TrueMAB 포맷으로 제공. 액상 형태, 1 mg/mL 농도, PBS/BSA/glycerol 버퍼에 보관. Toll-like receptor 신호전달 연구용.
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Applications
- Western Blot (WB)
Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2H3 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–245 of human PELI1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS with 1% BSA, 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The Pellino proteins are a highly homologous family of E3 ubiquitin ligases that act as upstream mediators in Toll-like receptor (TLR) pathways leading to activation of MAP kinases and transcription factors.
Pellino 1 is required for interleukin-1-mediated signaling through its interaction with the IRAK4–IRAK–TRAF6 complex, resulting in NF-κB activation.
Like other members of the Pellino family, Pellino 1 catalyzes polyubiquitination of IRAK1 and is activated via phosphorylation by IRAK1/IRAK4 or IKK-related kinases (IKK-ε, TBK1).
Its activity is also modulated by ubiquitination and sumoylation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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