Thermo Fisher Scientific AANAT Polyclonal Antibody
AANAT 단백질을 검출하기 위한 Thermo Fisher Scientific의 고순도 폴리클로날 항체. Western blot 및 IHC(P) 실험에 최적화. 인간 및 랫트 반응성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 재현성 제공.
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Thermo Fisher Scientific AANAT Polyclonal Antibody
Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to residues in Human AANAT |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719450 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
Arylalkylamine N-Acetyltransferase (AANAT) is the penultimate enzyme in melatonin synthesis. Melatonin plays a key role in sleep and circadian rhythm regulation. Large changes in AANAT abundance are responsible for day/night variations in melatonin synthesis in the pineal gland and retina. AANAT activity is mainly regulated by controlling steady-state protein levels, but recent studies suggest additional mechanisms may influence melatonin production independently of AANAT protein levels, explaining the rapid rise in circulating melatonin at the onset of darkness in humans.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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