Thermo Fisher Scientific Pro-NRG1 Polyclonal Antibody
Pro-NRG1 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC, Flow cytometry, ELISA 등에 사용 가능합니다. Protein A로 정제되었으며, -20°C에서 보관합니다. 연구용으로만 사용하십시오.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from mouse Pro-NRG1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Neuregulin 1 (NRG1) was originally identified as a 44-kD glycoprotein that interacts with the NEU/ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. A wide variety of NRG1 isoforms are generated through alternative splicing, including heregulins (HRGs), glial growth factors (GGFs), and sensory and motor neuron-derived factor (SMDF). These isoforms are tissue-specific and differ significantly in structure.
- HRG isoforms contain immunoglobulin (Ig) and epidermal growth factor-like (EGF-like) domains.
- GGF and GGF2 isoforms include a kringle-like sequence plus Ig and EGF-like domains.
- SMDF isoform shares only the EGF-like domain with other isoforms.
All NRG1 isoforms interact with ERBB family tyrosine kinase receptors to induce growth and differentiation of epithelial, neuronal, glial, and other cell types.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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