Thermo Fisher Scientific HVEM Monoclonal Antibody (10C6)

Thermo Fisher Scientific HVEM Monoclonal Antibody (10C6)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/mL.

HVEM (CD270) is a type I transmembrane protein and a member of the TNFR superfamily with a molecular weight of approximately 30 kDa. It is expressed on hematopoietic cells including T cells, B cells, dendritic cells, monocytes, neutrophils, and NK cells. HVEM regulates lymphocyte activation and immune homeostasis, and activates NF-κB through the TNF-related cytokine LIGHT during T cell activation.

Target Information

TNFRSF14, a member of the TNF-receptor superfamily, acts as a cellular mediator for herpes simplex virus (HSV) entry via binding of viral glycoprotein D (gD). Its cytoplasmic region interacts with TRAF family members to mediate signal transduction pathways that activate immune responses. Activation of TNFRSF14 in T cells promotes proliferation and cytokine production, contributing to inflammation and enhanced CTL-mediated tumor immunity. These properties suggest TNFRSF14 as a potential target for modulating cellular immune responses. Multiple alternatively spliced transcript variants have been identified, though some full-length forms remain undetermined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.