Thermo Fisher Scientific HVEM Monoclonal Antibody (10C6)

Applications

Tested Dilution

Publications

Flow Cytometry (Flow)

1- 5 µg/mL

-

ELISA (ELISA)

0.01-0.05 µg/mL

-

Product Specifications

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

10C6

Immunogen

Recombinant HVEM protein

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Wet ice

Product Specific Information

Reconstitute the lyophilized antibody with deionized water (or equivalent) to a final concentration of 0.5 mg/ml.

HVEM, also known as CD270, is a type 1 transmembrane protein. It is a member of the TNFR superfamily with a molecular weight of 30kDa. HVEM is expressed on hematopoietic cells such as T cells, B cells, dendritic cells, monocytes, neutrophils and NK cells. It participates in regulating lymphocyte activation and homeostasis in immune responses. HVEM activates NF-kB through the TNF-related cytokine LIGHT during T cell activation.

Target Information

TNFRSF14 is a member of the TNF-receptor superfamily. TNFRSF14 was identified as a cellular mediator of herpes simplex virus (HSV) entry. Binding of HSV viral envelope glycoprotein D (gD) to TNFRSF14 has been shown to be part of the viral entry mechanism. The cytoplasmic region of TNFRSF14 was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. Activation of the signal transduction pathway involving TNFRSF14 in T cells stimulates T cell proliferation and cytokine production, leading to inflammation and enhanced CTL-mediated tumor immunity, suggesting that these proteins may be useful as potential targets for controlling cellular immune responses. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these TNFRSF14 variants have not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.