Thermo Fisher Scientific MUPP1 Polyclonal Antibody
Rabbit polyclonal antibody against human MUPP1 for WB and IHC applications. Recognizes synthetic peptide (aa 1100–1200) region. Supplied lyophilized, unconjugated, and preservative-free. Suitable for research use only with stable storage at -20°C.
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Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:300–1:2,000 | – |
| Immunohistochemistry (IHC) | 1:300–1:2,000 | – |
| Miscellaneous PubMed (Misc) | – | View 2 publications |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / Ig |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide from amino acid region 1100–1200 of human MUPP1 conjugated to an immunogenic carrier protein |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | Not determined |
| Storage Buffer | Whole serum |
| Contains | No preservative |
| Storage Conditions | Store at 4°C for short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for stability. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Reconstitute in 100 µL of sterile water.
- Centrifuge to remove any insoluble material.
- Specificity: MUPP1.
Target Information
MUPP1 (multi PDZ domain protein 1, MPDZ) was discovered as an interacting partner with the 5-HT2C receptor and co-localizes with 5-HT2A and 5-HT2C receptors in various regions of the mouse brain, including the choroid plexus.
It contains 13 PDZ domains without catalytic activity and is concentrated in tight junctions of polarized epithelial cells. MUPP1 binds to claudin-1 and junctional adhesion molecule (JAM), functioning as a scaffold protein that recruits various proteins to tight junctions. It also interacts with claudin-8 and may contribute to tight junction barrier function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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