Thermo Fisher Scientific CLIC5 Polyclonal Antibody
CLIC5 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 IHC에 사용 가능. 인간 반응성, 고순도 Affinity Chromatography 정제. 청각 관련 연구 및 세포막 이온 통로 연구에 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.2–1 µg/mL |
| Immunohistochemistry (IHC) | 5 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide directed towards the C-terminal of human CLIC5 (aa 361–410) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS with 2% sucrose |
| Contains | 0.09% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2576896 |
Product Specific Information
Peptide sequence:
YRNYDIPAEM TGLWRYLKNA YARDEFTNTC AADSEIELAY ADVAKRLSRS
Sequence homology:
Cow: 100%
Dog: 93%
Guinea Pig: 100%
Horse: 100%
Human: 100%
Mouse: 93%
Rabbit: 100%
Rat: 100%
Zebrafish: 92%
Target Information
Clic5 encodes a protein required for normal hearing and formation of stereocilia in the inner ear. It can insert into membranes and form ion channels that may transport chloride ions. Clic5 plays a role in transepithelial ion absorption and secretion, and is essential for maintaining proper glomerular endothelial cell and podocyte architecture. The Clic5 gene belongs to the chloride intracellular channel (CLIC) family and associates with actin-based cytoskeletal structures. It is involved in hair cell stereocilia formation, myoblast proliferation, and glomerular maintenance. Multiple alternatively spliced transcript variants exist.
Diseases associated with CLIC5 include Deafness, Autosomal Recessive 103, and Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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