Thermo Fisher Scientific DIO2 Polyclonal Antibody
Rabbit polyclonal antibody against human DIO2 protein for WB, IHC, and Flow applications. Reacts with human and mouse; predicted cross-reactivity with pig. High purity via Protein A and antigen affinity chromatography. Supplied as 2 mg/mL liquid, uncon...
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 | - |
| Flow Cytometry (Flow) | 1:10–1:50 | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide between 165–191 amino acids of human DIO2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2635085 |
Product Specific Information
Predicted to react with pig based on sequence homology.
Target Information
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine through outer ring deiodination to bioactive 3,3’,5-triiodothyronine. This process involves residues encoded by the UGA codon, which normally signals translation termination. The 3’ UTR of Sec-containing genes has a common stem-loop structure, the Sec insertion sequence, necessary for recognition of UGA as a Sec codon rather than a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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