Thermo Fisher Scientific TrxR1 Polyclonal Antibody
TrxR1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB, IHC, ICC/IF 등 다양한 응용에 적합. Human 및 Mouse 반응성 확인. 고순도 항원 친화 크로마토그래피 정제, 1 mg/mL 농도. 산화 스트레스 연구 및 셀레늄 대사 관련 연구에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:3,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:1,000 | – |
| Immunocytochemistry (ICC/IF) | 1:100–1:1,000 | – |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fragment corresponding to a region within amino acids 69–313 of TrxR1 (Uniprot ID#Q16881) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 10% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at −20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2552037 |
Product Specific Information
- Recommended positive control: HepG2
- Predicted reactivity: Mouse (87%), Rat (87%), Dog (89%), Pig (89%), Rabbit (92%), Chicken (81%), Rhesus Monkey (99%), Chimpanzee (99%), Bovine (90%)
- Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
This gene encodes a member of the family of pyridine nucleotide oxidoreductases.
This protein reduces thioredoxins as well as other substrates and plays a role in selenium metabolism and protection against oxidative stress.
The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. Each subunit contains a selenocysteine (Sec) residue required for catalytic activity.
The selenocysteine is encoded by the UGA codon that normally signals translation termination.
The 3′ UTR of selenocysteine-containing genes has a stem-loop structure (SECIS) necessary for recognition of UGA as a Sec codon rather than a stop signal.
Alternative splicing results in several transcript variants encoding the same or different isoforms.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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