Thermo Fisher Scientific FAP1 Polyclonal Antibody
FAP1/PTPN13 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. 다양한 응용(IHC, ICC/IF, Flow, ELISA)에 사용 가능하며, 고순도의 Protein A 정제 제품. 연구용으로 세포 신호 조절 및 Fas 매개 세포사 연구에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| Flow Cytometry (Flow) | 1:20–1:100 |
| ELISA | 1:500–1:1,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human FAP1/PTPN13, amino acids 801–900 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | −20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate cellular processes such as growth, differentiation, mitotic cycle, and oncogenic transformation.
This large intracellular protein contains a catalytic PTP domain at the C-terminus and structural regions with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements.
It interacts with and dephosphorylates Fas receptor and IkappaBalpha, suggesting a role in Fas-mediated programmed cell death. It also interacts with GTPase-activating protein, indicating a regulatory function in Rho signaling pathways.
Four alternatively spliced transcript variants encoding distinct proteins have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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