Thermo Fisher Scientific Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Thermo Fisher Scientific Human EIF2AK2 (PKR), GST Tag Recombinant Protein

Applications

• Kinase Assay (KA)

Tested Dilution

• Assay-dependent

Product Specifications

Product Specific Information

• For maximum recovery, please spin prior to use.
• Aliquots of 5 µg, 10 µg, and 20 µg sizes are not recommended; use original packaging until exhausted.
• For larger sizes, aliquot preparation can reduce freeze/thaw cycles (do not prepare aliquots below 20 µL).
• Never store kinase diluted.
• Properly stored at -80°C, product guaranteed for 6 months from date of purchase.
• Protein Form: Catalytic

Target Information

EIF2AK2 (PKR) is one of four kinases that phosphorylate Ser51 of eIF2-alpha in response to environmental stresses. It plays a key role in antiviral defense through activation by double-stranded RNA during viral infection. PKR is involved in IFN-induced antiviral response, virus-induced apoptosis, and cell growth regulation. It up-regulates Fas expression and mediates FADD/Caspase-8 signaling. PKR activates both survival and death pathways via kinase-dependent and independent mechanisms. It also regulates NF-kappaB, p53, p38, and PDGF signaling pathways, and is implicated in tumor suppression and neurodegenerative diseases such as Alzheimer’s, Huntington’s, and ALS. Viruses can inhibit PKR activity, e.g., influenza virus NS1 protein.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.