Thermo Fisher Scientific CBF beta Recombinant Rabbit Monoclonal Antibody (23GB3785)

Applications and Tested Dilution

• Western Blot (WB): 1:1,000–1:5,000
• Flow Cytometry (Flow): 1:2,000

Product Specifications

Target Information

The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family, which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2).
The beta subunit is a non-DNA binding regulatory subunit that allosterically enhances DNA binding by the alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, and GM-CSF promoters.

Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta fused with the C-terminal portion of smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia (M4Eo subtype). Two transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.