Thermo Fisher Scientific CTDSP1 Monoclonal Antibody (OTI1G1), TrueMAB
CTDSP1 단백질을 표적으로 하는 Mouse IgG1 단일클론 항체로, Western blot 및 IHC(P)에서 검증됨. 인간 시료 반응성, 무보존제, 동결건조 형태로 제공. 연구용으로 전사 억제 관련 기전 연구에 적합.
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Applications
- Western Blot (WB): 1:2,000
- Immunohistochemistry (Paraffin) (IHC (P)): 1:150
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1G1 |
| Immunogen | Full length human recombinant protein of human CTDSP1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional round of desalting using Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL (Product #89882).
Target Information
CTDSP1 is a class 2C phosphatase dependent on the conserved DxD motif. Expression of CTDSP1 inhibits activated transcription from various promoter-reporter constructs, while phosphatase-inactive mutants enhance transcription.
REST/NRSF complex recruits SCPs to neuronal genes containing RE1 elements, silencing neuronal gene expression in nonneuronal cells.
Phosphatase-inactive SCP forms interfere with REST/NRSF function, promoting neuronal differentiation.
SCP activity is an evolutionarily conserved transcriptional regulator that globally silences neuronal genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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