Thermo Fisher Scientific TREX2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant protein corresponding to Human TREX2. Recombinant protein control fragment (Product #RP-101552). if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TREX2,uniProtId:Q9BQ50-2,ncbiNodeId:9606,antigenRange:6-54,antigenLength:236,antigenImageFileName:PA5-62906_TREX2_Q9BQ50-2_Rabbit.svg,antigenImageFileNamePDP:PA5-62906_TREX2_Q9BQ50-2_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 40% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2648899

Product Specific Information

Immunogen sequence: RAETFVFLDL EATGLPSVEP EIAELSLFAV HRSSLENPEH DESGALVLP

Highest antigen sequence identity to the following orthologs: Mouse - 86%, Rat - 86%.

Target Information

TREX2 is one of two major human 3to 5 exonucleases which are required for checkpoint signaling after DNA damage. While the related protein TREX1 is required for ATR expression and mutations in this gene result in Aicardi-Goutieres syndrome, chilblain lupus, and Cree encephalitis, less is known about TREX2. Like TREX1, TREX2 is ubiquitously expressed in all tissues examined. X-ray crystallography studies of TREX2-single strand DNA complexes revealed that TREX2 binds DNA as a dimer and may act to displace the second DNA strand, suggesting that TREX2 unzips and denatures double stranded DNA and feed the substrate DNA strand into the TREX2 active site. At least two isoforms of TREX2 are known to exist.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.