Thermo Fisher Scientific CHMP4B+CHMP4C Polyclonal Antibody
CHMP4B 및 CHMP4C 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체. Western blot, IHC, ICC, ELISA 등 다양한 응용에 적합. 고순도 Protein A 정제, 안정적인 액상 형태로 제공. 연구용으로만 사용 가능.
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- BS-7744R
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- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:300 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:100–1:500 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
| ELISA | 1:5,000–1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH conjugated synthetic peptide derived from human CHMP4B/CHMP4C |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | 0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Probable core component of the endosomal sorting required for transport complex III (ESCRT-III), which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) generated by invagination and scission from the limiting membrane of the endosome, mostly delivered to lysosomes enabling degradation of membrane proteins such as stimulated growth factor receptors, lysosomal enzymes, and lipids. The MVB pathway requires sequential function of ESCRT-O, -I, -II, and -III complexes. ESCRT-III proteins dissociate from the invaginating membrane before ILV release. The ESCRT machinery also functions in topologically equivalent membrane fission events such as terminal stages of cytokinesis and budding of enveloped viruses (HIV-1 and other lentiviruses).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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