Thermo Fisher Scientific CD8 alpha Monoclonal Antibody (YTS169.4), Biotin
Thermo Fisher CD8 alpha 단클론 항체(YTS169.4), Biotin 결합형. 마우스 시료 반응성, Rat IgG2b 아이소타입. Flow cytometry 및 IHC(F) 적용 가능. 단백질 G 정제, PBS/BSA buffer에 보존. 연구용으로 T세포 표지 및 면역분석에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Flow Cytometry (Flow) | 0.5 µg / 1×10⁶ cells | 1 publication |
| Miscellaneous PubMed (Misc) | - | 2 publications |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | YTS169.4 |
| Immunogen | Murine thymocytes (Target: CD8, UniProt ID: P01731-1, Antigen range: 1–247, Antigen length: 247) |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 4–5 mg/mL BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C and avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2538992 |
Available Conjugate Formats
Target Information
Cluster of differentiation 8 (CD8) is a type I transmembrane glycoprotein of the immunoglobulin receptor family. It plays a critical role in signal transduction, T cell differentiation, and activation.
CD8 is predominantly expressed on T cells as a disulfide-linked heterodimer (CD8α and CD8β), functioning as a co-receptor with T cell receptor (TCR) for MHC class I molecules.
The CD8α chain is essential for MHC-I binding and is also expressed as homodimers on subsets of T cells, NK cells, monocytes, and dendritic cells.
Engagement of MHC-I/peptide complexes triggers recruitment of Lck kinase, leading to lymphokine production, motility, and cytotoxic T lymphocyte (CTL) activation.
Activated CTLs play a key role in eliminating pathogens and tumor cells. Differentiation of naïve CD8⁺ T cells into CTLs is enhanced by IL-2, IL-12, and TGF-β1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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