Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience

Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience

Applications

• Flow Cytometry (Flow)
  Tested Dilution: 0.25 µg/test
  View 2 publications

Product Specifications

Available Formats

• Unconjugated
• PE
• Request custom conjugation

Product Specific Information

The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It acts as a cellular mediator of herpes simplex virus (HSV) entry through interaction with viral envelope glycoprotein D (gD).

The cytoplasmic region of HVEM binds to TRAF family members, mediating signal transduction pathways that activate immune responses. HVEM also serves as a unique ligand for BTLA (B and T lymphocyte attenuator), a conserved interaction between mouse and human that regulates lymphocyte activation and immune homeostasis.

Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Validated for flow cytometric staining of normal human peripheral blood cells at ≤0.25 µg/test (100 µL final volume). Cell numbers may range from 10⁵ to 10⁸ cells/test. Antibody titration is recommended for optimal performance.

Target Information

TNFRSF14 (HVEM) is a TNF-receptor superfamily member involved in HSV entry. Binding of HSV glycoprotein D to TNFRSF14 participates in viral entry. The cytoplasmic region interacts with TRAF proteins, activating signal transduction pathways that promote T cell proliferation and cytokine production. This leads to inflammation and enhanced CTL-mediated tumor immunity, making TNFRSF14 a potential target for immune modulation research. Multiple alternatively spliced transcript variants exist, though not all are fully characterized.

For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.