Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience
HVEM 단백질을 인식하는 mouse IgG1 단클론 항체로, Biotin으로 표지되어 있습니다. 인간 시료에 반응하며 유세포 분석(Flow Cytometry)에 최적화되어 있습니다. HSV 감염 및 면역 반응 연구용으로 적합하며, 4°C 암소 보관 권장됩니다.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience
Thermo Fisher Scientific CD270 (HVEM) Monoclonal Antibody (eBioHVEM-122), Biotin, eBioscience
Applications
- Flow Cytometry (Flow)
Tested Dilution: 0.25 µg/test
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Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Mouse |
| Host / Isotype | Mouse / IgG1 |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBioHVEM-122 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_837115 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
Product Specific Information
The eBioHVEM-122 antibody reacts with Herpes Virus Entry Mediator (HVEM, TR2), a member of the TNF-receptor superfamily. HVEM is expressed on most cell types, including T cells, B cells, monocytes, neutrophils, and dendritic cells. It acts as a cellular mediator of herpes simplex virus (HSV) entry through interaction with viral envelope glycoprotein D (gD).
The cytoplasmic region of HVEM binds to TRAF family members, mediating signal transduction pathways that activate immune responses. HVEM also serves as a unique ligand for BTLA (B and T lymphocyte attenuator), a conserved interaction between mouse and human that regulates lymphocyte activation and immune homeostasis.
Applications Reported: Suitable for flow cytometric analysis.
Applications Tested: Validated for flow cytometric staining of normal human peripheral blood cells at ≤0.25 µg/test (100 µL final volume). Cell numbers may range from 10⁵ to 10⁸ cells/test. Antibody titration is recommended for optimal performance.
Target Information
TNFRSF14 (HVEM) is a TNF-receptor superfamily member involved in HSV entry. Binding of HSV glycoprotein D to TNFRSF14 participates in viral entry. The cytoplasmic region interacts with TRAF proteins, activating signal transduction pathways that promote T cell proliferation and cytokine production. This leads to inflammation and enhanced CTL-mediated tumor immunity, making TNFRSF14 a potential target for immune modulation research. Multiple alternatively spliced transcript variants exist, though not all are fully characterized.
For Research Use Only.
Not for use in diagnostic procedures or resale without express authorization.
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