Thermo Fisher Scientific Dectin 2 Monoclonal Antibody (3D1)
Dectin-2 단백질을 인식하는 Mouse IgG3 단일클론 항체로, Western blot, IHC, Flow cytometry에 사용 가능. 인간 및 비인간 영장류 반응성. 단백질 G 정제, 액상 형태, 1 mg/mL 농도. 연구용으로만 사용.
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Thermo Fisher Scientific Dectin 2 Monoclonal Antibody (3D1)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200 |
| Flow Cytometry (Flow) | 0.5 µg / 5×10⁵ cells |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Non-human primate |
| Host / Isotype | Mouse / IgG3, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 3D1 |
| Immunogen | Blend of two peptides corresponding to amino acids 44–63 and 90–106 of human Dectin-2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2537768 |
Target Information
Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages, and inflammatory monocytes. It is a type II membrane receptor with a short cytoplasmic tail and a C-terminal C-type lectin domain. Dectin-2 recognizes high mannose structures and mediates cytokine production from antigen-presenting cells. Although it lacks obvious signaling motifs in its cytoplasmic tail, Dectin-2 utilizes FcRγ for internalization and activation of the NF-κB pathway. Despite sharing only 20–25% homology with Dectin-1, it functions similarly as a pattern recognition receptor (PRR) for fungal infections, activating both innate (Syk-CARD9 pathway) and adaptive immune responses. Thus, Dectin-2 serves as a connector between innate and adaptive immunity at the dendritic cell level.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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