Thermo Fisher Scientific Dectin 2 Monoclonal Antibody (3D1)

Applications

Tested Dilution

Publications

Western Blot (WB)

2-5 µg/mL

-

Immunohistochemistry (Paraffin) (IHC (P))

1:200

-

Flow Cytometry (Flow)

0.5 µg/5x10^5 cells

-

Product Specifications

Species Reactivity

Human, Non-human primate

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

3D1

Immunogen

A blend of two peptides made to amino acids 44-63 and 90-106 of human Dectin-2. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Dectin 2,uniProtId:Q6EIG7-1,ncbiNodeId:9606,antigenRange:44-63|90-106,antigenLength:209,antigenImageFileName:MA5-16250_Dectin_2_Q6EIG7-1_House_mouse.svg,antigenImageFileNamePDP:MA5-16250_Dectin_2_Q6EIG7-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2537768

Target Information

Dectin-2 is a C-type lectin expressed by dendritic cells, macrophages and inflammatory monocytes. It is a type II membrane receptor, with a short cytoplasmic tail, and a C-terminal C-type lectin domain. Dectin-2 is a receptor with specificity for high mannose structures and mediates cytokine production from DC and other antigen presenting cells. Though, Dectin-2 has no obvious signaling motifs attached to CP tail, reports indicate that Dectin-2 employs FcRg for internalization and to activate NF-kappaB pathway for cytokine production. Though it shares only 20-25% of homology with Dectin-1, it functions similarly as pattern recognition receptor (PRR) for fungal infections, to activate both innate (Syk-CARD9 innate signaling pathway) and adaptive immune responses (by activation of DC) to fungal infections. Thus Dectin-2 is a connector molecule of both innate and adaptive immunity functioning at DC level.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.