Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
Human ERN1/IRE1 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 ELISA에 적합합니다. 보존제가 없는 액상 형태이며 Protein A 및 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific IRE1 alpha Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1:25,000–1:50,000 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant Human ERN1/IRE1 Protein (Pro465–Leu977) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification | Protein A, Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | No preservative |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C (avoid freeze/thaw cycles) |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2787896 |
Product Specific Information
This product is preservative-free. It is recommended to add sodium azide (final concentration 0.05%–0.1%) to avoid contamination.
This antibody specifically recognizes Human ERN1/IRE1.
Target Information
ERN1 (endoplasmic reticulum to nucleus signaling 1) encodes a serine/threonine kinase with endoribonuclease activity, acting as a sensor of unfolded proteins in the ER. It transmits unfolded protein signals to the nucleus by splicing XBP1 mRNA, converting it into a potent transcriptional activator of the unfolded protein response.
IRE1 is essential for cell viability under ER stress conditions; depletion or inhibition leads to apoptosis during stress. ERN1 also plays a critical role in extraembryonic cells, vital for fetal development.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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