Thermo Fisher Scientific USP8 Monoclonal Antibody (460CT35.1.6)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:4,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

460CT35.1.6

Immunogen

KLH conjugated synthetic peptide between 1-30 amino acids from the C-terminal region of human USP8 if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:USP8,uniProtId:P40818-1,ncbiNodeId:9606,antigenRange:1-30,antigenLength:1118,antigenImageFileName:MA5-37573_USP8_P40818-1_House_mouse.svg,antigenImageFileNamePDP:MA5-37573_USP8_P40818-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

Conc. Not Determined

Storage buffer

ascites, pH 7.4

Contains

0.09% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2897503

Target Information

USP8 is a ubiquitin specific protease that plays an important regulatory role at the level of protein turnover by preventing degradation. USP8 is involved in cell proliferation, and probably regulates the stability of STAM2 and RASGRF1. USP8 may regulate T-cell energy mediated by RNF128 via the formation of a complex containing RNF128 and STAM2. As revealed by structure/function studies, USP8 forms a ternary complex with RNF128 and OTUB1, and interacts with the SH3 domain of STAM2 and RASGRF1. Expression of USP8 is induced Upon growth stimulation in starved human fibroblasts, and expression decreases in response to growth arrest induced by cell-cell contact.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.