Thermo Fisher Scientific CD276 (B7-H3) Monoclonal Antibody (M3.2D7)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

Recombinant rat monoclonal antibodies are produced using in vitro expression systems. Recombinant antibodies are generated by cloning specific antibody genes into an expression vector for controlled expression.
Advantages include:

• Improved specificity
• Lot-to-lot consistency
• Broader immunoreactivity due to diverse immune repertoire

It is recommended to titrate the antibody for optimal performance in the intended assay.

Target Information

CD276 (B7-H3) is a member of the B7 family of co-stimulatory molecules. It is a type I transmembrane protein that promotes CD4+ and CD8+ T cell proliferation, enhances cytotoxic T cell generation, and stimulates interferon gamma production.
Expression can be induced on dendritic cells and monocytes by inflammatory cytokines and is found in multiple tissues including heart, kidney, testis, and colon.
In humans, CD276 exists as two isoforms resulting from gene duplication and differential splicing.
CD276 has potential therapeutic relevance in regulating immune responses to cancer, particularly when combined with anti-angiogenic therapy.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.