Thermo Fisher Scientific Phospho-BTK (Tyr223) Recombinant Rabbit Monoclonal Antibody (ST51-05)
인간 BTK의 Tyr223 인산화 부위를 인식하는 재조합 토끼 단클론 항체. Western blot에 적합하며, 높은 특이성과 재현성을 제공. 액상 형태로 1 mg/mL 농도, 단백질 A로 정제됨. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): 1:1,000–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ST51-05 |
| Immunogen | Synthetic phospho-peptide corresponding to residues surrounding Tyr223 of human BTK |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | TBS, pH 7.4, with 0.05% BSA, 40% glycerol |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2899021 |
Target Information
Bruton tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase belonging to the SRC-related TEC subfamily of tyrosine kinases. Mutations in the BTK gene have been linked to severe developmental blocks in human B-cell ontogeny and immunodeficiency disorders.
BTK interacts with members of the toll-like receptor (TLR) family such as TLR4, 6, 8, and 9, which play critical roles in innate and adaptive immunity. It also interacts with key proteins in TLR4 signal transduction such as MyD88, TIRAP, and IRAK, but not TRAF-6, suggesting BTK involvement in lipopolysaccharide signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: MA5-41268_BTK_Q06187-1_Rabbit.svg, MA5-41268_BTK_Q06187-1_Rabbit_PDP.jpeg)
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