Thermo Fisher Scientific Cardiac Troponin I Polyclonal Antibody
Cardiac Troponin I 단백질을 검출하는 토끼 폴리클로날 항체로, WB 및 IHC(P) 실험에 적합합니다. 인간, 마우스, 설치류 등 다양한 종과 반응하며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로 심근 손상 마커 분석에 활용됩니다.
- 카탈로그번호
- PA599515
- 판매단위
- pk
카탈로그
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TNNI3 (Accession P19429), corresponding to amino acid residues K117–L167 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | −20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2818448 |
Product Specific Information
This antibody detects endogenous levels of total TNNI3.
Target Information
Cardiac Troponin I (TNNI3) is a cardiac-specific inhibitory protein that functions as part of the troponin complex with troponin C (TnC) and troponin T (TnT). It binds to actin in thin filaments of muscle tissue, regulating muscle contraction through calcium-dependent structural changes. Measurement of TnI and TnT levels in blood is a key diagnostic indicator of cardiac muscle damage and aids in differentiating angina from myocardial infarction. Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro. Mutations in the TNNI3 gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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