Thermo Fisher Scientific POLR1C Monoclonal Antibody (M1)
POLR1C 단백질을 인식하는 Mouse monoclonal antibody (Clone M1). Western blot, IHC, ELISA에 사용 가능. Human 반응성. Affinity chromatography로 정제된 액상형 항체로, PBS buffer에 보존. 연구용 전용 시약.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–5 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 0.6 µg/mL |
| ELISA | 0.3 ng/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | M1 |
| Immunogen | POLR1C (AAH08863, 1–346 a.a) full-length recombinant protein with GST tag (GST MW: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
MAASQAVEEM RSRVVLGEFG VRNVHTTDFP GNYSGYDDAW DQDRFEKNFR VDVVHMDENS LEFDMVGIDA AIANAFRRIL LAEVPTMAVE KVLVYNNTSI VQDEILAHRL GLIPIHADPR LFEYRNQGDE EGTEIDTLQF RLQVRCTRNP HAAKDSSDPN ELYVNHKVYT RHMTWIPLGN QADLFPEGTI RPVHDDILIA QLRPGQEIDL LMHCVKGIGK DHAKFSPVAT ASYRLLPDIT LLEPVEGEAA EELSRCFSPG VIEVQEVQGK KVARVANPRL DTFSREIFRN EKLKKVVRLA RVRDHYIFSV ESTGVLPPDV LVSEAIKVLM GKCRRFLDEL DAVQMD
Target Information
RNA polymerases transcribe nuclear genes for ribosomal RNA, thus representing ribosomal biogenesis.
RNA polymerase I (Pol I) is located in the nucleolus and transcribes class I genes, which code for large ribosomal RNA.
Different subunits of the Pol I transcription machinery are targets of various physiological stimuli, suggesting that multiple signaling pathways are involved in Pol I transcription.
RPA16, RPA40, and RPA135 are subunits of Pol I that associate early in RNA Pol I assembly.
RPA40 is essential for the function and integrity of the complex and is also an essential subunit of RNA polymerase III (Pol III).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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