Thermo Fisher Scientific CD206 Monoclonal Antibody (MR5D3), Biotin

Applications and Tested Dilution

Product Specifications

Additional Formats

• Unconjugated
• FITC
• PE
• Request custom conjugation

Product Specific Information

CD206 is expressed weakly at the cell surface, and staining may be increased following membrane permeabilization.
For FACS analysis, use 10 µL of the suggested working dilution to label 1×10⁶ cells in 100 µL.

Rat anti-mouse CD206 antibody, clone MR5D3, recognizes the mouse mannose receptor (CD206), a ~175 kDa type I membrane glycoprotein.

Target Information

CD206 (MSR, Mannose receptor, MRC1) is a 175 kDa transmembrane protein belonging to the group of pattern recognition receptors.
It is predominantly expressed in tissue macrophages, dendritic cells, a subpopulation of endothelial cells, and sperm cells.
CD206 plays roles in innate and adaptive immune responses, mediating recognition and uptake of macromolecules such as modified lipoproteins, AGEs, and amyloid β-protein (Aβ).

While normally involved in cell adhesion and host defense, CD206 has also been implicated in atherosclerosis and amyloid β deposition in Alzheimer’s disease.
Its gene encodes class A macrophage scavenger receptors (types 1, 2, and 3), generated by alternative splicing.
Types 1 and 2 mediate endocytosis of modified LDLs, while type 3 lacks this ability and can inhibit the function of the other isoforms, suggesting a regulatory mechanism.
CD206 dysfunction has been associated with diseases such as leprosy and Gaucher’s Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.